Key Takeaways:
- 1. Researchers used a technique involving a plasmid to introduce antibody genes into cells, with the help of electrical pulses disrupting cell membranes.
- 2. A study involving 44 participants tested the safety and efficacy of this method in humans.
- 3. The injection resulted in stable production of antibodies for at least 72 weeks, with minimal adverse reactions reported.
Researchers utilized a plasmid-based technique combined with electrical pulses to introduce antibody genes into cells, enabling muscle cells to produce antibodies in animal testing. A human study involving 44 participants demonstrated stable antibody production for at least 72 weeks, with minimal adverse reactions such as muscle pain and skin reddening reported. Injecting more DNA or increasing the number of injections enhanced antibody production, showcasing the potential of this approach.
Insight: The study highlights a promising method of inducing stable antibody production in humans using a plasmid and electrical pulses, with implications for developing therapeutic strategies leveraging the body's own cells.
This article was curated by memoment.jp from the feed source: Ars Technica.
Read the original article here: https://arstechnica.com/science/2025/10/dna-and-jolts-of-electricity-get-people-to-make-optimal-antibodies/
© All rights belong to the original publisher.
